A case of bupropion-associated delirium

J Clin Psychiatry. 1990 Jul;51(7):307-8.


The authors report a case of bupropion-associated delirium characterized by disorganized thinking, memory impairment, fear, and agitation but not disorientation, delusions, hallucinations, or other perceptual distortions. Symptom onset appeared to be dose-related, and a sustained therapeutic response was subsequently obtained at a lower dose of bupropion without recurrence of delirium. Abnormal bupropion metabolism and elevated plasma metabolite levels did not account for the adverse reaction, which instead was hypothesized to reflect dopaminergic effects of bupropion.

Publication types

  • Case Reports

MeSH terms

  • Antidepressive Agents / administration & dosage
  • Antidepressive Agents / adverse effects*
  • Antidepressive Agents / pharmacokinetics
  • Bupropion
  • Delirium / chemically induced*
  • Depressive Disorder / drug therapy
  • Depressive Disorder / psychology
  • Dose-Response Relationship, Drug
  • Humans
  • Male
  • Middle Aged
  • Propiophenones / administration & dosage
  • Propiophenones / adverse effects*
  • Propiophenones / pharmacokinetics


  • Antidepressive Agents
  • Propiophenones
  • Bupropion