How the vertebrates were made: selective pruning of a double-duplicated genome

BMC Biol. 2010 Dec 13;8:144. doi: 10.1186/1741-7007-8-144.


Vertebrates are the result of an ancient double duplication of the genome. A new study published in BMC Biology explores the selective retention of genes after this event, finding an extensive enrichment of signaling proteins and transcription factors. Analysis of their expression patterns, interactions and subsequent history reflect the forces that drove their evolution, and with it the evolution of vertebrate complexity.

MeSH terms

  • Animals
  • Evolution, Molecular*
  • Gene Duplication*
  • Genome*
  • Vertebrates / genetics*