The folding of single domain proteins--have we reached a consensus?

Curr Opin Struct Biol. 2011 Feb;21(1):12-24. doi: 10.1016/ Epub 2010 Dec 6.


Rather than stressing the most recent advances in the field, this review highlights the fundamental topics where disagreement remains and where adequate experimental data are lacking. These topics include properties of the denatured state and the role of residual structure, the nature of the fundamental steps and barriers, the extent of pathway heterogeneity and non-native interactions, recent comparisons between theory and experiment, and finally, dynamical properties of the folding reaction.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Diffusion
  • Humans
  • Kinetics
  • Models, Molecular
  • Protein Folding*
  • Protein Structure, Tertiary
  • Proteins / chemistry*


  • Proteins