Male meiosis: Y keep it silenced?

Curr Biol. 2010 Dec 7;20(23):R1022-4. doi: 10.1016/j.cub.2010.11.002.


What drives defective spermatocytes into apoptosis during mid-pachytene? A recent study identifies the first mid-pachytene 'killer' genes: two Y-linked transcription factors, the Zfy1/2 gene pair, must be silenced to avoid apoptosis.

Publication types

  • Comment

MeSH terms

  • Animals
  • Apoptosis / genetics
  • Female
  • Gene Silencing
  • Humans
  • Male
  • Meiosis*
  • Spermatocytes / physiology*
  • Transcription Factors / genetics
  • Y Chromosome*


  • Transcription Factors