Membrane budding

Cell. 2010 Dec 10;143(6):875-87. doi: 10.1016/j.cell.2010.11.030.


Membrane budding is a key step in vesicular transport, multivesicular body biogenesis, and enveloped virus release. These events range from those that are primarily protein driven, such as the formation of coated vesicles, to those that are primarily lipid driven, such as microdomain-dependent biogenesis of multivesicular bodies. Other types of budding reside in the middle of this spectrum, including caveolae biogenesis, HIV-1 budding, and ESCRT-catalyzed multivesicular body formation. Some of these latter events involve budding away from cytosol, and this unusual topology involves unique mechanisms. This Review discusses progress toward understanding the structural and energetic bases of these different membrane-budding paradigms.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Membrane Structures / chemistry
  • Cell Membrane Structures / metabolism*
  • Cytoplasmic Vesicles / chemistry
  • Cytoplasmic Vesicles / metabolism*
  • Endosomal Sorting Complexes Required for Transport / metabolism
  • Eukaryotic Cells / chemistry
  • Eukaryotic Cells / metabolism
  • Humans


  • Endosomal Sorting Complexes Required for Transport