The chromatin signaling pathway: diverse mechanisms of recruitment of histone-modifying enzymes and varied biological outcomes

Mol Cell. 2010 Dec 10;40(5):689-701. doi: 10.1016/j.molcel.2010.11.031.

Abstract

Posttranslational modifications of histones are coupled in the regulation of the cellular processes involving chromatin, such as transcription, replication, repair, and genome stability. Recent biochemical and genetic studies have clearly demonstrated that many aspects of chromatin, in addition to posttranslational modifications of histones, provide surfaces that can interact with effectors and the modifying machineries in a context-dependent manner, all as a part of the "chromatin signaling pathway." Here, we have reviewed recent findings on the molecular basis for the recruitment of the chromatin-modifying machineries and their diverse and varied biological outcomes.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Chromatin / enzymology*
  • Chromatin / metabolism
  • Histones / metabolism*
  • Humans
  • Models, Genetic
  • Signal Transduction*
  • Transcription, Genetic

Substances

  • Chromatin
  • Histones