Mechanisms of centrosome separation and bipolar spindle assembly

Dev Cell. 2010 Dec 14;19(6):797-806. doi: 10.1016/j.devcel.2010.11.011.


Accurate segregation of chromosomes during cell division is accomplished through the assembly of a bipolar microtubule-based structure called the mitotic spindle. Work over the past two decades has identified a core regulator of spindle bipolarity, the microtubule motor protein kinesin-5. However, an increasing body of evidence has emerged demonstrating that kinesin-5-independent mechanisms driving bipolar spindle assembly exist as well. Here, we discuss different pathways that promote initial centrosome separation and bipolar spindle assembly.

Publication types

  • Review

MeSH terms

  • Animals
  • Biomechanical Phenomena
  • Cell Division / physiology*
  • Centrosome / physiology*
  • Humans
  • Kinesin / physiology
  • Kinetochores / physiology
  • Microtubules / physiology
  • Models, Biological
  • Molecular Motor Proteins / physiology
  • Nuclear Envelope / physiology
  • Prophase / physiology
  • Spindle Apparatus / physiology*


  • Molecular Motor Proteins
  • Kinesin