GTPases in intracellular trafficking: an overview

Semin Cell Dev Biol. 2011 Feb;22(1):1-2. doi: 10.1016/j.semcdb.2010.12.004. Epub 2010 Dec 9.


Small GTPases that belong to the ras sub-families of Rab, Arf, and Rho, and the large GTPase dynamin, regulate intracellular trafficking. This issue of Seminars of Cell and Developmental Biology highlights topics regarding mechanisms by which these GTPases regulate the different steps of vesicular transport: vesicle formation, scission, targeting and fusion. In addition, the emerging roles of GTPases in coordination of individual transport steps as well as coordination of intracellular trafficking with other cellular processes are reviewed. Finally, common structures and mechanisms underlying the function of the ras-like GTPases and the importance of their function to human health and disease are discussed.

Publication types

  • Editorial
  • Introductory Journal Article

MeSH terms

  • Animals
  • GTP Phosphohydrolases / metabolism*
  • Humans
  • Intracellular Space / metabolism*
  • Protein Transport


  • GTP Phosphohydrolases