Casein kinase 1: Complexity in the family

Int J Biochem Cell Biol. 2011 Apr;43(4):465-9. doi: 10.1016/j.biocel.2010.12.004. Epub 2010 Dec 9.


The CK1 family of serine/threonine kinases regulates diverse cellular processes, through binding to and phosphorylation a myriad of protein substrates. CK1 prefers substrates primed by prior phosphorylation, and works closely with other kinases in the Wnt pathway. CK1 is itself regulated by posttranslational modification, including autophosphorylation. We provide a brief overview of the fundamentals of CK1 biology with an emphasis on scaffold binding and kinase regulation in Wnt signaling and circadian rhythms.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Casein Kinase I / chemistry*
  • Casein Kinase I / metabolism*
  • Circadian Rhythm
  • Enzyme Activation
  • Gene Expression Regulation, Enzymologic
  • Humans
  • Neoplasms / enzymology


  • Casein Kinase I