Assembly of infectious hepatitis C virus particles

Trends Microbiol. 2011 Feb;19(2):95-103. doi: 10.1016/j.tim.2010.11.005. Epub 2010 Dec 14.


A hallmark of the hepatitis C virus (HCV) replication cycle is its tight link with host cell lipid synthesis. This is best illustrated by the peculiar pathway used for the assembly of infectious HCV particles. Research in the past few years has shown that formation of HC-virions is closely connected to lipid droplets that could serve as an assembly platform. Moreover, HCV particle production appears to be strictly linked to very-low-density lipoproteins. In this review, we focus on new insights into the molecular aspects of the architecture and assembly of this unique type of virus particle.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Hepacivirus / physiology*
  • Hepatitis C / virology
  • Humans
  • Virion
  • Virus Assembly*