Abstract
Mycobacterium ulcerans infection is responsible for severe skin lesions in sub-Saharan Africa. We enrolled 30 Beninese patients with Buruli ulcers in a pilot study to evaluate efficacy of an oral chemotherapy using rifampicin plus clarithromycin during an 8-week period. The treatment was well tolerated, and all patients were healed by 12 months after initiation of therapy without relapse.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Oral
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Adolescent
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Adult
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Aged
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Anti-Bacterial Agents / administration & dosage*
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Anti-Bacterial Agents / adverse effects
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Benin
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Buruli Ulcer / drug therapy*
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Child
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Child, Preschool
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Clarithromycin / administration & dosage
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Clarithromycin / adverse effects
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Drug Therapy, Combination / methods
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Female
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Humans
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Male
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Middle Aged
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Mycobacterium ulcerans / isolation & purification*
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Pilot Projects
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Rifampin / administration & dosage
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Rifampin / adverse effects
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Treatment Outcome
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Young Adult
Substances
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Anti-Bacterial Agents
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Clarithromycin
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Rifampin