Resuscitation and coagulation in the severely injured trauma patient

Philos Trans R Soc Lond B Biol Sci. 2011 Jan 27;366(1562):192-203. doi: 10.1098/rstb.2010.0220.


Developments in the resuscitation of the severely injured trauma patient in the last decade have been through the increased understanding of the early pathophysiological consequences of injury together with some observations and experiences of recent casualties of conflict. In particular, the recognition of early derangements of haemostasis with hypocoagulopathy being associated with increased mortality and morbidity and the prime importance of tissue hypoperfusion as a central driver to this process in this population of patients has led to new resuscitation strategies. These strategies have focused on haemostatic resuscitation and the development of the ideas of damage control resuscitation and damage control surgery continuum. This in turn has led to a requirement to be able to more closely monitor the physiological status, of major trauma patients, including their coagulation status, and react in an anticipatory fashion.

Publication types

  • Review

MeSH terms

  • Blood Coagulation Disorders / etiology
  • Blood Coagulation Disorders / physiopathology*
  • Clinical Protocols*
  • Humans
  • Military Medicine / methods*
  • Military Medicine / trends
  • Military Personnel
  • Resuscitation / methods*
  • Shock / etiology
  • Shock / physiopathology*
  • Warfare*
  • Wounds and Injuries / complications
  • Wounds and Injuries / physiopathology*
  • Wounds and Injuries / therapy*