Advanced magnetic resonance imaging with histopathological correlation in papillary tumor of pineal region: report of a case and review of literature

Neurol India. 2010 Nov-Dec;58(6):928-32. doi: 10.4103/0028-3886.73750.


Papillary tumors of the pineal region are recently described as rare mass lesions with limited literature available on their natural history and imaging features. Magnetic resonance imaging (MRI) including perfusion, diffusion, and spectroscopic features were described in an 18-year-old girl with papillary tumor of pineal region. A well-defined, T1 hyperintense and contrast-enhancing mass lesion was noted in pineal region with few cystic spaces within. Solid portion of lesion showed minimal diffusion restriction with average apparent diffusion coefficient of 0.812 Χ 10 -3 mm 2 /s; on MR spectroscopy elevated myo-inositol peak with reduced N-acetylaspartate and elevated choline in the tumor. On perfusion study there was significantly high relative cerebral blood volume (rCBV) (6-9 times) and relative cerebral blood flow (rCBF). Our findings agree with previous descriptions of cystic areas with T1 hyperintense appearance of this tumor but very high level of tumor perfusion, diffusion restriction, and presence of myo-inositol peak are important imaging findings and may correlate with the recent reports of high tumor recurrence in these cases.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adolescent
  • Aspartic Acid / analogs & derivatives
  • Brain Neoplasms / diagnosis*
  • Brain Neoplasms / metabolism
  • Carcinoma, Papillary / diagnosis*
  • Carcinoma, Papillary / metabolism
  • Cerebrovascular Circulation
  • Choline
  • Diagnostic Imaging / methods*
  • Female
  • Humans
  • Pineal Gland* / diagnostic imaging
  • Pineal Gland* / pathology
  • Pinealoma / diagnosis*
  • Pinealoma / metabolism
  • Radiography
  • Radionuclide Imaging


  • Aspartic Acid
  • N-acetylaspartate
  • Choline