Multiple functions of the S-phase checkpoint mediator

Biosci Biotechnol Biochem. 2010;74(12):2367-73. doi: 10.1271/bbb.100583. Epub 2010 Dec 7.

Abstract

There is mounting evidence that replication defects are the major source of spontaneous genomic instability in cells, and that S-phase checkpoints are the principal defense against such instability. The S-phase checkpoint mediator protein Mrc1/Claspin mediates the checkpoint response to replication stress by facilitating phosphorylation of effector kinase by a sensor kinase. In this review, the multiple functions and the regulation of the S-phase checkpoint mediator are discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Cycle Proteins / chemistry
  • Cell Cycle Proteins / metabolism*
  • DNA Replication
  • Enzyme Activation
  • Humans
  • Protein Kinases / metabolism
  • Protein Stability
  • S Phase*

Substances

  • Cell Cycle Proteins
  • Protein Kinases