The meaning of interaction

Hum Hered. 2010;70(4):269-77. doi: 10.1159/000321967. Epub 2010 Dec 8.


Although recent studies have attempted to dispel the confusion that exists in regard to the definition, analysis and interpretation of interaction in genetics, there still remain aspects that are poorly understood by non-statisticians. After a brief discussion of the definition of gene-gene interaction, the main part of this study addresses the fundamental meaning of statistical interaction and its relationship to measurement scale, disproportionate sample sizes in the cells of a two-way table and gametic phase disequilibrium.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Data Interpretation, Statistical
  • Epistasis, Genetic
  • Genetic Phenomena*
  • Germ Cells
  • Humans
  • Linkage Disequilibrium
  • Models, Genetic*
  • Models, Statistical*
  • Terminology as Topic