Synthesis of (2R, 3R)-epigallocatechin-3-O-(4-hydroxybenzoate), a novel catechin from Cistus salvifolius, and evaluation of its proteasome inhibitory activities

Kumi Osanai; Congde Huo; Kristin R Landis-Piwowar; Q Ping Dou; Tak Hang Chan

doi:10.1016/j.tet.2007.05.043

Synthesis of (2R, 3R)-epigallocatechin-3-O-(4-hydroxybenzoate), a novel catechin from Cistus salvifolius, and evaluation of its proteasome inhibitory activities

Tetrahedron. 2007 Aug 6;63(32):7565-7570. doi: 10.1016/j.tet.2007.05.043.

Authors

Kumi Osanai¹, Congde Huo, Kristin R Landis-Piwowar, Q Ping Dou, Tak Hang Chan

Affiliation

¹ Department of Applied Biology and Chemical Technology and the Open Laboratory for Chiral Technology, the Institute of Molecular Technology for Drug Discovery and Synthesis, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR, China.

Abstract

The total and semi syntheses of (2R, 3R)-epigallocatechin-3-O-(4-hydroxybenzoate), a novel catechin from Cistus salvifolius, was accomplished. The proteasome inhibition and cytotoxic activities of the synthetic compound and its acetyl derivative were studied and compared with (2R, 3R)-epigallocatechin-3-gallate (EGCG), the active component from green tea.

Abstract

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