Compartmentalization of TNF-receptor 1 signaling: TNF-R1-associated caspase-8 mediates activation of acid sphingomyelinase in late endosomes

Adv Exp Med Biol. 2011:691:605-16. doi: 10.1007/978-1-4419-6612-4_64.

Authors

Uwe Bertsch¹, Bärbel Edelmann, Vladimir Tchikov, Supandi Winoto-Morbach, Stefan Schütze

Affiliation

¹ Institute of Immunology, University Hospital of Schleswig-Holstein, Campus Kiel, Michaelisstr. 5, Kiel D-24105, Germany.

PMID: 21153367
DOI: 10.1007/978-1-4419-6612-4_64

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Apoptosis
Caspase 8 / metabolism*
Cathepsin D / metabolism
Cell Compartmentation*
Death Domain Receptor Signaling Adaptor Proteins / metabolism
Endocytosis
Endosomes / enzymology*
Enzyme Activation
Humans
Mice
Models, Biological
Protein Processing, Post-Translational
Receptors, Tumor Necrosis Factor, Type I / metabolism*
Signal Transduction*
Sphingomyelin Phosphodiesterase / metabolism*

Substances

Death Domain Receptor Signaling Adaptor Proteins
Receptors, Tumor Necrosis Factor, Type I
Sphingomyelin Phosphodiesterase
Caspase 8
Cathepsin D