The substrates of Plk1, beyond the functions in mitosis

Protein Cell. 2010 Nov;1(11):999-1010. doi: 10.1007/s13238-010-0131-x. Epub 2010 Dec 10.

Abstract

Polo-like kinase 1 (Plk1) is a key regulator of cell division in eukaryotic cells. In this short review, we briefly summarized the well-established functions modulated by Plk1 during mitosis. Beyond mitosis, we focused mainly on the unexpected processes in which Plk1 emerges as a critical player, including microtubule dynamics, DNA replication, chromosome dynamics, p53 regulation, and recovery from the G2 DNA-damage checkpoint. Our discussion is mainly based on the critical substrates targeted by Plk1 during these cellular events and the functional significance associated with each phosphorylation event.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Cycle
  • Cell Cycle Proteins / chemistry
  • Cell Cycle Proteins / metabolism*
  • Chromosomes / metabolism
  • DNA Replication
  • Humans
  • Microtubules / metabolism
  • Mitosis
  • Protein-Serine-Threonine Kinases / chemistry
  • Protein-Serine-Threonine Kinases / metabolism*
  • Proto-Oncogene Proteins / chemistry
  • Proto-Oncogene Proteins / metabolism*
  • Tumor Suppressor Protein p53 / metabolism

Substances

  • Cell Cycle Proteins
  • Proto-Oncogene Proteins
  • Tumor Suppressor Protein p53
  • Protein-Serine-Threonine Kinases
  • polo-like kinase 1