[Bronchial challenge tests]

Pneumologie. 2011 Jun;65(6):340-6. doi: 10.1055/s-0030-1255967. Epub 2010 Dec 10.
[Article in German]


This is an updated overview of indications, contraindications, performance and interpretation of bronchial challenge tests. As speciality, the diagnostic step by step scheme comprises in addition to the clinical case history a detailed exposure (occupational) history, lung function testing, assessment of nonspecific bronchial hyperresponsiveness, allergological diagnostics (skin prick test, measurement of specific IgE antibodies), privation and reexposure test and as gold standard specific bronchial challenge tests. The last mentioned tests are of particular importance in the framework of a diagnostic backup with regard to specific therapeutic and preventive measures and insurance regulations (occupational disease?). Specific bronchial challenge tests and their variant, the workplace-related challenge test, serve to objectify or exclude the clinical relevance and the current state of a respiratory sensitization. They require a comprehensive experience of the physician performing the tests. The majority of diseases does not necessitate these tests, especially if case history, lung function testing, allergy tests, privation and reexposure test provide unanimously positive results. If allergic symptoms of conjunctiva or the upper respiratory tract are of prime importance the performance of a specific conjunctival or nasal challenge test is recommended.

Publication types

  • Review

MeSH terms

  • Allergens
  • Alveolitis, Extrinsic Allergic / diagnosis
  • Asthma / diagnosis*
  • Asthma / therapy
  • Asthma, Occupational / diagnosis
  • Asthma, Occupational / therapy
  • Bronchial Hyperreactivity / diagnosis*
  • Bronchial Hyperreactivity / therapy
  • Bronchial Provocation Tests / methods*
  • Bronchoconstrictor Agents
  • Contraindications
  • Humans
  • Isocyanates
  • Methacholine Chloride
  • Predictive Value of Tests
  • Respiratory Function Tests


  • Allergens
  • Bronchoconstrictor Agents
  • Isocyanates
  • Methacholine Chloride
  • 4,4'-diphenylmethane diisocyanate