Elucidation of the α-keto-aldehyde binding mechanism: a lead structure motif for proteasome inhibition

Angew Chem Int Ed Engl. 2011 Jan 10;50(2):542-4. doi: 10.1002/anie.201005488.

Authors

Melissa Ann Gräwert¹, Nerea Gallastegui, Martin Stein, Boris Schmidt, Peter-Michael Kloetzel, Robert Huber, Michael Groll

Affiliation

¹ Center for Integrated Protein Science at the Department Chemie, Lehrstuhl für Biochemie, Technische Universität München, Lichtenbergstrasse 4, 85748 München, Germany.

PMID: 21154547
DOI: 10.1002/anie.201005488

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aldehydes / chemistry*
Binding Sites
Catalytic Domain
Computer Simulation
Cyclization
Drug Evaluation, Preclinical
Ketones / chemistry*
Peptides / chemistry
Proteasome Endopeptidase Complex / metabolism
Proteasome Inhibitors*
Protein Binding
Schiff Bases / chemistry

Substances

Aldehydes
Ketones
Peptides
Proteasome Inhibitors
Schiff Bases
Proteasome Endopeptidase Complex