The legumain protease-activated auristatin prodrugs suppress tumor growth and metastasis without toxicity

ChemMedChem. 2011 Jan 3;6(1):54-9. doi: 10.1002/cmdc.201000478.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Aminobenzoates* / administration & dosage
  • Aminobenzoates* / chemical synthesis
  • Animals
  • Breast Neoplasms / drug therapy*
  • Breast Neoplasms / enzymology
  • Breast Neoplasms / pathology
  • Cell Line, Tumor
  • Cysteine Endopeptidases / metabolism*
  • Disease Models, Animal
  • Enzyme Activation / drug effects
  • Female
  • Humans
  • Mice
  • Neoplasm Metastasis / drug therapy
  • Neoplasm Metastasis / prevention & control
  • Oligopeptides* / administration & dosage
  • Oligopeptides* / chemical synthesis
  • Prodrugs* / administration & dosage
  • Prodrugs* / chemical synthesis
  • Tumor Burden / drug effects
  • Weight Loss / drug effects

Substances

  • Aminobenzoates
  • Oligopeptides
  • Prodrugs
  • auristatin
  • Cysteine Endopeptidases
  • asparaginylendopeptidase