The intergenic spacer region of the ribosomal RNA gene of Penicillium marneffei shows almost no DNA sequence diversity

Nanthawan Mekha; Takashi Sugita; Koichi Makimura; Natteewan Poonwan; Pathom Sawanpanyalert; Reiko Ikeda; Akemi Nishikawa

doi:10.1111/j.1348-0421.2010.00270.x

The intergenic spacer region of the ribosomal RNA gene of Penicillium marneffei shows almost no DNA sequence diversity

Microbiol Immunol. 2010 Nov;54(11):714-6. doi: 10.1111/j.1348-0421.2010.00270.x.

Authors

Nanthawan Mekha¹, Takashi Sugita, Koichi Makimura, Natteewan Poonwan, Pathom Sawanpanyalert, Reiko Ikeda, Akemi Nishikawa

Affiliation

¹ Department of Medical Sciences, National Institute of Health, Nonthaburi, 11000, Thailand.

PMID: 21155364
DOI: 10.1111/j.1348-0421.2010.00270.x

Abstract

The fungus Penicillium marneffei causes fatal systemic infections and is endemic in many parts of South-East Asia, especially Thailand. The intergenic spacer (IGS) region, the most variable region of rRNA genes, was found to be highly conserved among 58 P. marneffei strains. IGS analysis might not be suitable for molecular epidemiological analysis of P. marneffei infections.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Base Sequence
DNA, Fungal / chemistry*
DNA, Ribosomal Spacer / chemistry*
Genes, rRNA*
Humans
Penicillium / genetics*

Substances

DNA, Fungal
DNA, Ribosomal Spacer