Non-stem cell origin for oligodendroglioma

Cancer Cell. 2010 Dec 14;18(6):669-82. doi: 10.1016/j.ccr.2010.10.033.


Malignant astrocytic brain tumors are among the most lethal cancers. Quiescent and therapy-resistant neural stem cell (NSC)-like cells in astrocytomas are likely to contribute to poor outcome. Malignant oligodendroglial brain tumors, in contrast, are therapy sensitive. Using magnetic resonance imaging (MRI) and detailed developmental analyses, we demonstrated that murine oligodendroglioma cells show characteristics of oligodendrocyte progenitor cells (OPCs) and are therapy sensitive, and that OPC rather than NSC markers enriched for tumor formation. MRI of human oligodendroglioma also suggested a white matter (WM) origin, with markers for OPCs rather than NSCs similarly enriching for tumor formation. Our results suggest that oligodendroglioma cells show hallmarks of OPCs, and that a progenitor rather than a NSC origin underlies improved prognosis in patients with this tumor.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens / analysis
  • Benzamides / pharmacology
  • Brain Neoplasms / pathology*
  • Cell Differentiation
  • Cell Line, Tumor
  • Dacarbazine / analogs & derivatives
  • Dacarbazine / pharmacology
  • Diphenylamine / analogs & derivatives
  • Diphenylamine / pharmacology
  • Humans
  • Mice
  • Mitogen-Activated Protein Kinases / antagonists & inhibitors
  • Neural Stem Cells / pathology*
  • Oligodendroglia / pathology*
  • Oligodendroglioma / pathology*
  • Oncogene Proteins v-erbB / analysis
  • Proteoglycans / analysis
  • Temozolomide
  • Tumor Suppressor Protein p53 / physiology


  • Antigens
  • Benzamides
  • Oncogene Proteins v-erbB
  • Proteoglycans
  • Tumor Suppressor Protein p53
  • chondroitin sulfate proteoglycan 4
  • Dacarbazine
  • mirdametinib
  • Diphenylamine
  • Mitogen-Activated Protein Kinases
  • Temozolomide