Cytotoxic amide alkaloids from Piper boehmeriaefolium

J Nat Prod. 2011 Jan 28;74(1):45-9. doi: 10.1021/np100606u. Epub 2010 Dec 15.

Abstract

Eight new amide alkaloids (1-8) and 19 known ones were isolated from the whole plant of Piper boehmeriaefolium. Their structures were determined through spectroscopic data analyses. Cytotoxic activity of these amides against human cervical carcinoma HeLa cells was evaluated, and 1-[(9E)-10-(3,4-methylenedioxyphenyl)-9-decenoyl]pyrrolidine (9) exhibited significant inhibitory activity with an IC(50) value of 2.7 μg/mL.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemistry
  • Alkaloids / isolation & purification*
  • Alkaloids / pharmacology*
  • Amides / chemistry
  • Amides / isolation & purification*
  • Amides / pharmacology*
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Drug Screening Assays, Antitumor
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / isolation & purification*
  • Drugs, Chinese Herbal / pharmacology*
  • Female
  • HeLa Cells
  • Humans
  • Inhibitory Concentration 50
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Piper / chemistry*
  • Pyrrolidines / chemistry
  • Pyrrolidines / isolation & purification*
  • Pyrrolidines / pharmacology*
  • Stereoisomerism

Substances

  • 1-((9E)-10-(3,4-methylenedioxyphenyl)-9-decenoyl)pyrrolidine
  • Alkaloids
  • Amides
  • Antineoplastic Agents, Phytogenic
  • Drugs, Chinese Herbal
  • Pyrrolidines