Hemorrhage remains the leading cause of death in combat and the primary cause of preventable death after civilian trauma. Over the last 10 years, major improvements in hemostatic agents have resulted in new dressings that are replacing gauze as the standard of care for compressible hemorrhage. This has inspired a plethora of hemostatic products, some of which have been used in the combat and civilian sector. These dressings are crucial in their ability to control initial hemorrhage so that transfer to a higher level of care can occur, thereby potentially improving survival. Current research is ongoing to determine which of the available hemostatic agents is the most efficacious. The current recommendation by the Committee on Tactical Combat Casualty Care is that Combat Gauze™ (Z-Medica) is the hemostatic dressing of choice and every soldier carries this dressing in their first aid kit. This article reviews novel hemostatic agents used by first responders in the military and civilian sectors.