Congenital self-healing reticulohistiocytosis - an important diagnostic challenge

Acta Paediatr. 2011 May;100(5):784-6. doi: 10.1111/j.1651-2227.2010.02123.x. Epub 2011 Jan 11.


Aim: To present current and new knowledge on congenital self-healing reticulohistiocytosis, a benign variant of cutaneous Langerhans cell histiocytosis presenting with skin lesions in the neonatal period.

Methods: We describe and photo document two cases of this rare disease and review the literature.

Results: Only few newborns have acute access to a neonatal dermatologist, and we demonstrate how the spontaneous cutaneous involution may happen even prior to the first dermatological assessment. As no sole criterion can reliably distinguish the self-healing form from disseminated disease, multidisciplinary assessment and follow-up are essential.

Conclusion: Our data document how easily the diagnosis congenital self-healing reticulocytosis may be missed and emphasize the importance and value of instant clinical photographing at the neonatal unit and the use of teledermatology whenever congenital self-healing reticulohistiocytosis is suspected.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Diagnosis, Differential
  • Histiocytosis, Langerhans-Cell / congenital*
  • Histiocytosis, Langerhans-Cell / diagnosis
  • Humans
  • Infant, Newborn
  • Male
  • Skin Diseases / etiology