Clinicopathologic and immunohistochemical profile of ovarian metastases from colorectal carcinoma

World J Gastrointest Surg. 2010 Apr 27;2(4):109-16. doi: 10.4240/wjgs.v2.i4.109.


Metastasis of colorectal adenocarcinoma of the ovary is not an uncommon occurrence and ovarian metastases from colorectal carcinoma frequently mimic endometrioid and mucinous primary ovarian carcinoma. The clinical and pathologic features of metastatic colorectal adenocarcinoma involving the ovary is reviewed with particular focus on the diagnostic challenge of distinguishing these secondary ovarian tumors from primary ovarian neoplasm. Immunohistochemical stains that may be useful in the differential diagnosis of metastatic colorectal tumors to the ovary and primary ovarian tumors are detailed.

Keywords: Colon; Colorectal carcinoma; Endometrioid adenocarcinoma; Immunohistochemistry; Metastatic carcinoma; Mucinous carcinoma; Ovary.