Three novel NEIL1 promoter polymorphisms in gastric cancer patients

World J Gastrointest Oncol. 2010 Feb 15;2(2):117-20. doi: 10.4251/wjgo.v2.i2.117.


Aim: To identify genetic polymorphisms in the promoter region of the human base excision repair gene NEIL1 in gastric cancer patients.

Methods: The NEIL1 promoter region in DNA from 80 Japanese patients with gastric cancer was searched for genetic polymorphisms by polymerase chain reaction-single-strand conformation polymorphism and subsequent sequencing analyses.

Results: Three novel genetic polymorphisms, i.e. c.-3769C>T, c.-3170T>G, and c.-2681TA[8], were identified in the NEIL1 promoter region at an allele frequency of 0.6%, 9.4%, and 4.4%, respectively, in Japanese gastric cancer patients.

Conclusion: Three NEIL1 promoter polymorphisms detected in this study may be of importance in gastric carcinogenesis.

Keywords: Base excision repair; Gastric cancer; Genetic polymorphism; NEIL1.