Liver function tests: Association with cardiovascular outcomes

World J Hepatol. 2010 Apr 27;2(4):143-5. doi: 10.4254/wjh.v2.i4.143.

Abstract

An association between nonalcoholic fatty liver disease and cardiovascular disease has been repeatedly reported. Several studies have focused on levels of gamma-glutamyltransferase (GGT) and alanine aminotransferase (ALT) in relation to cardiovascular outcomes. Evidence indicates that GGT may have a potential role for cardiovascular risk stratification while the role of ALT for cardiac prognosis remains controversial. A conceptual framework that includes not only GGT and ALT but also markers of hepatocyte apoptosis such as cytokeratin-18 fragments should be developed.

Keywords: Cardiovascular disease; Liver function tests; Nonalcoholic fatty liver disease; Outcomes.