Use of sodium aurothiomalate during lactation

Br J Clin Pharmacol. 1990 Jun;29(6):777-9. doi: 10.1111/j.1365-2125.1990.tb03703.x.

Abstract

The report concerns a mother who breast fed her infant whilst receiving sodium aurothiomalate for the treatment of rheumatoid arthritis. The milk:serum concentration ratio was not constant, reflecting the non-concurrence of the concentration-time profiles of gold in milk and maternal serum after i.m. injection. Gold was detected in the infant's serum. Calculations indicate that the weight-adjusted dose to the infant exceeded that received by the mother.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Arthritis, Rheumatoid / drug therapy
  • Arthritis, Rheumatoid / metabolism
  • Female
  • Gold / blood
  • Gold / metabolism
  • Gold Sodium Thiomalate / blood
  • Gold Sodium Thiomalate / pharmacokinetics*
  • Gold Sodium Thiomalate / therapeutic use
  • Humans
  • Infant
  • Injections, Intramuscular
  • Lactation*
  • Milk, Human / metabolism*
  • Pregnancy

Substances

  • Gold Sodium Thiomalate
  • Gold