A proposal for identifying the low renal uric acid clearance phenotype

Arthritis Res Ther. 2010;12(6):149. doi: 10.1186/ar3191. Epub 2010 Dec 16.

Abstract

Investigation of the genetic basis of hyperuricaemia is a subject of intense interest. However, clinical studies commonly include hyperuricaemic patients without distinguishing between 'over-producers' or 'under-excretors' of urate. The statistical power of studies of genetic polymorphisms of genes encoding renal urate transporters is diluted if 'over-producers' of uric acid are included. We propose that lower than normal fractional renal clearance of urate is a better inclusion criterion for these studies. We also propose that a single daytime spot urine sample for calculation of fractional renal clearance of urate should be preferred to calculation from 24-hour urine collections.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Humans
  • Hyperuricemia* / etiology
  • Hyperuricemia* / genetics
  • Hyperuricemia* / metabolism
  • Kidney / metabolism
  • Kidney / physiopathology*
  • Kidney Function Tests / methods*
  • Organic Anion Transporters / genetics
  • Organic Anion Transporters / metabolism
  • Phenotype
  • Uric Acid / metabolism*

Substances

  • Organic Anion Transporters
  • urate transporter
  • Uric Acid