High plasma nesfatin-1 level in patients with major depressive disorder

Prog Neuropsychopharmacol Biol Psychiatry. 2011 Mar 30;35(2):497-500. doi: 10.1016/j.pnpbp.2010.12.004. Epub 2010 Dec 14.


Aim: In the present study, our aim was to determine the changes in the plasma concentrations of a recently discovered peptide hormone nesfatin-1 in patients with major depressive disorder and then to make a comparison with the control group.

Method: Subjects in the patient group were randomly selected from Mustafa Kemal University, Medical School, Research and Training Hospital, Psychiatry Department, Outpatient Clinic and subjects in the control group were selected from healthy volunteers. Healthy control subjects were matched in terms of weight and body mass index. Hamilton Depression Rating Scale (HAM-D) was applied to both groups. ELISA method was used for measurement of plasma nesfatin-1 levels.

Results: The average nesfatin-1 level was statistically higher in patients with major depressive disorder than in the control group (p<0.001). A positive correlation was observed between plasma nesfatin-1 levels and HAM-D scores both in the patient group (r=0.59, p<0.001) and in the control group (r=0.58, p<0.001).

Conclusion: Our findings suggest a possible relationship between major depressive disorder and high plasma nesfatin-1 level.

Publication types

  • Comparative Study

MeSH terms

  • Biomarkers / blood
  • Blood Glucose / analysis
  • Calcium-Binding Proteins / blood*
  • DNA-Binding Proteins / blood*
  • Depressive Disorder, Major
  • Female
  • Humans
  • Male
  • Nerve Tissue Proteins
  • Nucleobindins
  • Peptide Hormones / blood*
  • Psychiatric Status Rating Scales


  • Biomarkers
  • Blood Glucose
  • Calcium-Binding Proteins
  • DNA-Binding Proteins
  • NUCB2 protein, human
  • Nerve Tissue Proteins
  • Nucleobindins
  • Peptide Hormones