Multiple squamous cell carcinomas of the oral cavity in a young patient with graft-versus-host disease following allogenic bone marrow transplantation

Int J Oral Maxillofac Surg. 2011 May;40(5):556-8. doi: 10.1016/j.ijom.2010.11.008. Epub 2010 Dec 15.


The development of secondary malignancies is a potential long-term complication after haematopoietic stem cell transplantation (HSCT). In particular, a higher incidence of oral squamous cell carcinoma (OSCC) has been reported in patients experiencing chronic graft versus host disease (cGvHD) secondary to HSCT. This report describes the development of two synchronous SCC of the buccal mucosa in a young female patient treated with HSCT for beta thalassemia major. She had undergone HSCT at the age of 9 years and developed oral GvHD 6 months after transplant. 17 years after HSCT she developed two synchronous carcinomatous lesions on the tongue and floor of the mouth. The current case highlights the association between oral cGvHD and OSCC, and the possible development of OSCC in young patients even many years after HSCT. This evidence suggests closer follow-up for all patients treated with HSCT who developed cGvHD, and more effective strategies to prevent and treat cGvHD.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Bone Marrow Transplantation / adverse effects*
  • Carcinoma, Squamous Cell / etiology*
  • Female
  • Follow-Up Studies
  • Graft vs Host Disease / complications*
  • Hematopoietic Stem Cell Transplantation
  • Hepatitis C / etiology
  • Humans
  • Lichen Planus, Oral / etiology
  • Mouth Floor / pathology
  • Mouth Neoplasms / etiology*
  • Neoplasms, Multiple Primary / etiology*
  • Tongue Neoplasms / etiology*
  • Transplantation, Homologous
  • beta-Thalassemia / therapy