Treatment with marine collagen peptides modulates glucose and lipid metabolism in Chinese patients with type 2 diabetes mellitus

Appl Physiol Nutr Metab. 2010 Dec;35(6):797-804. doi: 10.1139/H10-075.


This study was aimed at examining the therapeutic effects of marine collagen peptides (MCPs) from fish hydrolysate in Chinese patients with type 2 diabetes mellitus (T2DM). A total of 100 diabetic patients and 50 healthy controls were recruited. Diabetic patients were randomized into treatment and control groups. The patients in the treatment group received an additional 13 g of MCPs daily for 3 months. Their blood samples were collected before, and 1.5 and 3 months after, treatment to evaluate glucose and lipid metabolism. The levels of serum high-sensitivity C-reactive protein (hs-CRP), nitric oxide (NO), bradykinin, prostacyclin (PGI2), and adipokines were determined. Significantly reduced levels of fasting blood glucose, human glycated hemoglobin A1c (GHbA1c), fasting blood insulin, total triglycerides, total cholesterol, low-density lipoprotein, and free-fatty acids, but increased levels of insulin sensitivity index and HDL were observed in T2DM patients following treatment with MCPs for 1.5 and 3 months. The values of these measures were significantly lower or higher than those of patient controls (p < 0.01), respectively. Interestingly, significantly decreased levels of hs-CRP and NO, but increased levels of bradykinin, PGI2, and adiponectin were detected in MCP-treated T2DM patients (p < 0.01), as compared with their basal values or the levels in patient controls. MCP treatment improved glucose and lipid metabolism in diabetic patients.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipokines / blood
  • Aged
  • Animals
  • Blood Glucose / analysis*
  • C-Reactive Protein / analysis
  • China
  • Collagen / metabolism
  • Collagen / therapeutic use
  • Diabetes Mellitus, Type 2 / blood*
  • Diabetes Mellitus, Type 2 / diet therapy*
  • Dietary Supplements*
  • Female
  • Fishes*
  • Glycated Hemoglobin A / analysis
  • Humans
  • Inflammation Mediators / blood
  • Insulin Resistance
  • Lipids / blood*
  • Male
  • Middle Aged
  • Nitric Oxide / blood
  • Protein Hydrolysates / chemistry
  • Protein Hydrolysates / therapeutic use*
  • Time Factors


  • Adipokines
  • Blood Glucose
  • Glycated Hemoglobin A
  • Inflammation Mediators
  • Lipids
  • Protein Hydrolysates
  • hemoglobin A1c protein, human
  • Nitric Oxide
  • Collagen
  • C-Reactive Protein