[Research advances on hydrogen therapy in nervous system diseases]

Zhejiang Da Xue Xue Bao Yi Xue Ban. 2010 Nov;39(6):638-43. doi: 10.3785/j.issn.1008-9292.2010.06.015.
[Article in Chinese]


Oxidative stress plays a pivotal role in the pathogenesis of varied nervous system diseases. Recent studies have demonstrated that hydrogen has selective antioxidative effect. It selectively reduces the hydroxyl radical (*OH) and peroxynitrite (ONOO(-)), the most cytotoxic of reactive oxygen species (ROS); however, it does not affect other ROS, which play important physiological roles at low concentrations. A large body of experimental studies has proved that hydrogen, through anti-oxidation, anti-inflammatory and inhibiting apoptosis, has a significant therapeutic effect in various neurological diseases, such as ischemia, hypoxia, degeneration and spinal cord contusion. It provides us with a new clinical method for the prevention and treatment of neurological diseases.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antioxidants / pharmacology*
  • Humans
  • Hydrogen / pharmacology*
  • Hydroxyl Radical / metabolism
  • Nervous System / drug effects
  • Nervous System / metabolism*
  • Nervous System Diseases / drug therapy*
  • Nervous System Diseases / metabolism
  • Oxidative Stress / drug effects*
  • Oxidative Stress / physiology
  • Peroxynitrous Acid / metabolism


  • Antioxidants
  • Peroxynitrous Acid
  • Hydroxyl Radical
  • Hydrogen