Synthesis of DNA-interactive pyrrolo[2,1-c][1,4]benzodiazepines (PBDs)

Chem Rev. 2011 Apr 13;111(4):2815-64. doi: 10.1021/cr100120f. Epub 2010 Dec 17.

Authors

Dyeison Antonow¹, David E Thurston

Affiliation

¹ Gene Targeting Drug Design Research Group, The School of Pharmacy, University of London, 29/39 Brunswick Square, London WC1N 1AX, UK. dyeison@yahoo.com

PMID: 21166464
DOI: 10.1021/cr100120f

No abstract available

Publication types

Review

MeSH terms

Animals
Benzodiazepines / chemical synthesis*
Benzodiazepines / chemistry
Benzodiazepines / pharmacology
DNA / metabolism
Humans
Models, Molecular
Pyrroles / chemical synthesis*
Pyrroles / chemistry
Pyrroles / pharmacology

Substances

Pyrroles
pyrrolo(2,1-c)(1,4)benzodiazepine
Benzodiazepines
DNA