Epithelial-mesenchymal transition in the skin

J Dermatol Sci. 2011 Jan;61(1):7-13. doi: 10.1016/j.jdermsci.2010.11.015. Epub 2010 Dec 5.

Abstract

Epithelial-mesenchymal transition (EMT) plays important roles not only in the morphogenesis but also in wound repair, tissue fibrosis and cancer progression. Recently, regulatory mechanism of this process has been elaborately elucidated. EMT can be a new therapeutic target for treating skin ulcer, fibrosing alopecia, and malignant cutaneous cancers, including squamous cell carcinoma and melanoma.

Publication types

  • Review

MeSH terms

  • Carcinoma, Squamous Cell / etiology
  • Carcinoma, Squamous Cell / metabolism
  • Epithelial-Mesenchymal Transition / physiology*
  • Fibrosis / pathology
  • Humans
  • Melanoma / etiology
  • Melanoma / metabolism
  • Signal Transduction
  • Skin / growth & development*
  • Skin / metabolism*
  • Skin / pathology
  • Skin Neoplasms / etiology
  • Skin Neoplasms / metabolism
  • Snail Family Transcription Factors
  • Transcription Factors / chemistry
  • Transcription Factors / metabolism*
  • Wound Healing / physiology

Substances

  • Snail Family Transcription Factors
  • Transcription Factors