Fecal lactoferrin and Clostridium spp. in stools of autistic children

Anaerobe. 2011 Feb;17(1):43-5. doi: 10.1016/j.anaerobe.2010.12.003. Epub 2010 Dec 16.


Stools from autistic and healthy children were studied for fecal lactoferrin, Clostridium difficile toxins, Clostridium perfringens enterotoxin and cultured for Clostridium spp. Elevated level of FLA was demonstrated in 24.4% stools, all from boys (31.25%). No toxins were detected. Clostridium spp. was isolated with similar frequency from all samples. C. perfringens were isolated significantly often from the autistic stools, intermediate sensitive strains to penicillin 19%, to clindamycin 11.3%, and to metronidazole 7.5% were detected. Further studies on fecal microflora and inflammatory mediators, with larger groups of patients, are required in order to explain their role in neurological deficits.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Anti-Bacterial Agents / pharmacology
  • Autistic Disorder*
  • Bacterial Toxins / analysis*
  • Child
  • Child, Preschool
  • Clostridium / isolation & purification*
  • Feces / chemistry*
  • Feces / microbiology*
  • Female
  • Humans
  • Lactoferrin / analysis*
  • Male
  • Microbial Sensitivity Tests


  • Anti-Bacterial Agents
  • Bacterial Toxins
  • LTF protein, human
  • Lactoferrin