Nuclear magnetic resonance spectra and molecular structure of mesna

G Hägele; M Batz; R Peters; U Niemeyer; J Engel

Nuclear magnetic resonance spectra and molecular structure of mesna

Arzneimittelforschung. 1990 May;40(5):599-602.

Authors

G Hägele¹, M Batz, R Peters, U Niemeyer, J Engel

Affiliation

¹ Institut für Anorganische Chemie und Strukturchemie, Heinrich-Heine-Universität Düsseldorf, Fed. Rep. of Germany.

PMID: 2116804

Abstract

Mesna (2-mercapto-ethane sulfonic acid sodium salt) is used as a reliably acting uroprotector in cancer chemotherapy with oxazaphosphorine cytostatics. 1H-, 13C[1H]- and C,H-COSY-NMR-spectra are analyzed. In solution state mesna exists predominantly in a trans-rotameric form. These findings are supported by hypothetical gas-phase-structures of mesna, simulated via the program system MOPAC.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Magnetic Resonance Spectroscopy
Mercaptoethanol / analogs & derivatives*
Mesna / analysis*
Models, Chemical
Molecular Structure

Substances

Mercaptoethanol
Mesna