Metastasis suppressors and the tumor microenvironment

Semin Cancer Biol. 2011 Apr;21(2):113-22. doi: 10.1016/j.semcancer.2010.12.005. Epub 2010 Dec 17.


The most lethal and debilitating attribute of cancer cells is their ability to metastasize. Throughout the process of metastasis, tumor cells interact with other tumor cells, host cells and a variety of molecules. Tumor cells are also faced with a number of insults, such as hemodynamic sheer pressure and immune selection. This brief review explores how metastasis suppressor proteins regulate interactions between tumor cells and the microenvironments in which tumor cells find themselves.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Adhesion Molecules / genetics
  • Cell Adhesion Molecules / metabolism
  • Extracellular Matrix / genetics
  • Extracellular Matrix / metabolism
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Neoplasm Metastasis / pathology*
  • Receptors, Cell Surface / metabolism
  • Signal Transduction
  • Tumor Microenvironment*
  • Tumor Suppressor Proteins / genetics
  • Tumor Suppressor Proteins / metabolism*


  • Cell Adhesion Molecules
  • Receptors, Cell Surface
  • Tumor Suppressor Proteins