Induction of a state of iron limitation in uropathogenic Escherichia coli CFT073 by cranberry-derived proanthocyanidins as revealed by microarray analysis

Gabriela Hidalgo; André Ponton; Julien Fatisson; Che O'May; Bahareh Asadishad; Tim Schinner; Nathalie Tufenkji

doi:10.1128/AEM.02201-10

Induction of a state of iron limitation in uropathogenic Escherichia coli CFT073 by cranberry-derived proanthocyanidins as revealed by microarray analysis

Appl Environ Microbiol. 2011 Feb;77(4):1532-5. doi: 10.1128/AEM.02201-10. Epub 2010 Dec 17.

Authors

Gabriela Hidalgo¹, André Ponton, Julien Fatisson, Che O'May, Bahareh Asadishad, Tim Schinner, Nathalie Tufenkji

Affiliation

¹ Dept. of Chemical Engineering, McGill University, Montreal, Quebec H3A 2B2, Canada.

Abstract

Transcriptional profiles of uropathogenic Escherichia coli CFT073 exposed to cranberry-derived proanthocyanidins (PACs) were determined. Our results indicate that bacteria grown on media supplemented with PACs were iron deprived. To our knowledge, this is the first time that PACs have been shown to induce a state of iron limitation in this bacterium.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bacterial Adhesion / drug effects
Gene Expression Profiling
Iron / metabolism
Iron Chelating Agents / pharmacology*
Microarray Analysis
Plant Extracts
Proanthocyanidins / pharmacology*
Reverse Transcriptase Polymerase Chain Reaction
Uropathogenic Escherichia coli / genetics
Uropathogenic Escherichia coli / growth & development
Uropathogenic Escherichia coli / metabolism*
Vaccinium macrocarpon / chemistry

Substances

Iron Chelating Agents
Plant Extracts
Proanthocyanidins
Iron

Associated data

GEO/GSE25745