The filamins: organizers of cell structure and function

Cell Adh Migr. Mar-Apr 2011;5(2):160-9. doi: 10.4161/cam.5.2.14401. Epub 2011 Mar 1.

Abstract

Filamin A (FLNa), the first non-muscle actin filament cross-linking protein, was identified in 1975. Thirty five years of FLNa research has revealed its structure in great detail, discovered its isoforms (FLNb and c), and identified over 90 binding partners including channels, receptors, intracellular signaling molecules, and even transcription factors. Due to this diversity, mutations in human FLN genes result in a wide range of anomalies with moderate to lethal consequences. This review focuses on the structure and functions of FLNa in cell migration and adhesion.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Actin Cytoskeleton / physiology
  • Actins / metabolism
  • Animals
  • Binding Sites
  • Cell Adhesion
  • Cell Movement / physiology*
  • Contractile Proteins / genetics
  • Contractile Proteins / metabolism*
  • Cytoskeleton / physiology
  • Filamins
  • Gene Expression
  • Heart Diseases / genetics
  • Humans
  • Mechanical Phenomena
  • Mice
  • Microfilament Proteins / genetics
  • Microfilament Proteins / metabolism*
  • Models, Molecular
  • Mutation*
  • Neoplasms / genetics
  • Neurodegenerative Diseases / genetics
  • Protein Binding
  • Protein Isoforms / genetics
  • Protein Isoforms / metabolism*
  • Protein Structure, Tertiary

Substances

  • Actins
  • Contractile Proteins
  • FLNB protein, human
  • Filamins
  • Microfilament Proteins
  • Protein Isoforms