Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation

Nat Chem Biol. 2011 Feb;7(2):75-7. doi: 10.1038/nchembio.496. Epub 2010 Dec 19.


The signaling mechanisms leading to the formation of neutrophil extracellular traps (NETs), relevant in infections, sepsis and autoimmune diseases, are poorly understood. Neutrophils are not amenable to studies with conventional genetic techniques. Using a new chemical genetic analysis we show that the Raf-MEK-ERK pathway is involved in NET formation through activation of NADPH oxidase and upregulation of antiapoptotic proteins. We identify potential targets for drugs addressing NET-associated diseases.

MeSH terms

  • Extracellular Signal-Regulated MAP Kinases / metabolism*
  • Humans
  • MAP Kinase Kinase Kinases / metabolism*
  • Neutrophils / metabolism*


  • Extracellular Signal-Regulated MAP Kinases
  • MAP Kinase Kinase Kinases

Associated data

  • PubChem-Substance/100053922
  • PubChem-Substance/100053923
  • PubChem-Substance/100053924
  • PubChem-Substance/100053925