Characterization of the proteome, diseases and evolution of the human postsynaptic density

Nat Neurosci. 2011 Jan;14(1):19-21. doi: 10.1038/nn.2719. Epub 2010 Dec 19.


We isolated the postsynaptic density from human neocortex (hPSD) and identified 1,461 proteins. hPSD mutations cause 133 neurological and psychiatric diseases and were enriched in cognitive, affective and motor phenotypes underpinned by sets of genes. Strong protein sequence conservation in mammalian lineages, particularly in hub proteins, indicates conserved function and organization in primate and rodent models. The hPSD is an important structure for nervous system disease and behavior.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Central Nervous System Diseases / genetics*
  • Evolution, Molecular*
  • Humans
  • Macaca
  • Mice
  • Mutation
  • Neocortex / metabolism*
  • Nerve Tissue Proteins / genetics*
  • Pan troglodytes
  • Post-Synaptic Density / genetics*
  • Proteome / genetics*
  • Rats
  • Species Specificity


  • Nerve Tissue Proteins
  • Proteome