Antibiotic prophylaxis during prolonged clean neurosurgery. Results of a randomized double-blind study using oxacillin

J Neurosurg. 1990 Sep;73(3):383-6. doi: 10.3171/jns.1990.73.3.0383.


The efficacy of oxacillin as a prophylaxis for infection was analyzed in a 27-month randomized double-blind study of 400 patients who had undergone clean neurosurgical interventions lasting longer than 2 hours. Four neurosurgeons took part in the study and 356 patients were eligible for final analysis. Among the 171 patients treated with oxacillin, there was one case of infection (0.6%), compared to nine (4.9%) of the 185 patients given a placebo. The difference between the two groups was statistically significant (p = 0.0398). This study, together with others (randomized or not), clearly demonstrates the efficacy of antibiotic prophylaxis in prolonged clean neurosurgery.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Chi-Square Distribution
  • Double-Blind Method
  • Female
  • Humans
  • Infection Control*
  • Male
  • Middle Aged
  • Neurosurgery / methods*
  • Oxacillin / administration & dosage
  • Oxacillin / therapeutic use*
  • Postoperative Complications / prevention & control*
  • Randomized Controlled Trials as Topic
  • Time Factors


  • Oxacillin