Do selective serotonin receptor inhibitor antidepressants reduce tamoxifen's effectiveness and increase the risk of death from breast cancer?

Breast Cancer Res. 2010 Dec 20;12 Suppl 4(Suppl 4):S18. doi: 10.1186/bcr2747.
No abstract available

MeSH terms

  • Antidepressive Agents, Second-Generation / adverse effects*
  • Antineoplastic Agents, Hormonal / metabolism*
  • Antineoplastic Agents, Hormonal / therapeutic use
  • Breast Neoplasms / drug therapy*
  • Breast Neoplasms / metabolism
  • Breast Neoplasms / mortality*
  • Cytochrome P-450 CYP2D6 / genetics
  • Cytochrome P-450 CYP2D6 / metabolism
  • Cytochrome P-450 CYP2D6 Inhibitors
  • Drug Interactions
  • Female
  • Humans
  • Receptors, Estrogen / analysis
  • Selective Serotonin Reuptake Inhibitors / adverse effects*
  • Serotonin Antagonists / adverse effects*
  • Tamoxifen / metabolism*
  • Tamoxifen / therapeutic use

Substances

  • Antidepressive Agents, Second-Generation
  • Antineoplastic Agents, Hormonal
  • Cytochrome P-450 CYP2D6 Inhibitors
  • Receptors, Estrogen
  • Serotonin Antagonists
  • Serotonin Uptake Inhibitors
  • Tamoxifen
  • Cytochrome P-450 CYP2D6