Multiple functions of the vesicular proton pump in nerve terminals

Lucia Tabares; Bill Betz

doi:10.1016/j.neuron.2010.12.012

Multiple functions of the vesicular proton pump in nerve terminals

Neuron. 2010 Dec 22;68(6):1020-2. doi: 10.1016/j.neuron.2010.12.012.

Authors

Lucia Tabares¹, Bill Betz

Affiliation

¹ Department of Medical Physiology and Biophysics, University of Seville, 41009 Seville, Spain.

PMID: 21172605
DOI: 10.1016/j.neuron.2010.12.012

Abstract

Synaptic vesicles are acidified by a proton pump (vATPase), which allows vesicular uptake of neurotransmitters. After vesicle exocytosis, continued operation of the vATPase would seem to serve no useful function. In this issue of Neuron, however, Zhang and colleagues show that continued pumping alkalinizes the cytoplasm, accelerating endocytosis.

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