Treatment of refractory status epilepticus in childhood

Curr Neurol Neurosci Rep. 2011 Apr;11(2):195-204. doi: 10.1007/s11910-010-0170-y.


Refractory status epilepticus (RSE) is characterized by a prolonged seizure that persists despite adequate initial management. RSE accounts for almost one quarter of all status epilepticus and carries significant risk for morbidity and mortality. Treatment varies widely between institutions regarding medication choice, dose, and monitoring. Several agents including nonanesthetic antiepileptic drugs (AEDs), anesthetic AEDs, enteral AEDs, and other therapies have been used in RSE. We review the current treatment strategies for RSE, focusing on patient selection, monitoring, optimal dosing and administration of medications, efficacy, adverse effects, and treatment duration.

MeSH terms

  • Anticonvulsants / administration & dosage
  • Anticonvulsants / therapeutic use*
  • Child
  • Electroconvulsive Therapy
  • Humans
  • Status Epilepticus / physiopathology*
  • Status Epilepticus / therapy*
  • Treatment Outcome


  • Anticonvulsants