The synapsins and the regulation of synaptic function

Bioessays. 1990 Jun;12(6):259-63. doi: 10.1002/bies.950120603.


Synapsin I and II are a family of synaptic vesicle-associated phosphoproteins involved in the short-term regulation of neurotransmitter release. In this review, we discuss a working model for the molecular mechanisms by which the synapsins act. We propose that synapsin I links synaptic vesicles to actin filaments in the presynaptic nerve terminal and that these interactions are modulated by the reversible phosphorylation of synapsin I through various signal transduction pathways. The high degree of homology between the synapsins suggests that some of the functional properties of synapsin I are also shared by synapsin II.

Publication types

  • Review

MeSH terms

  • Animals
  • Models, Neurological
  • Nerve Tissue Proteins / physiology*
  • Neuropeptides / physiology*
  • Phosphoproteins / physiology
  • Synapses / physiology*
  • Synapsins
  • Synaptic Vesicles / physiology*
  • Synaptic Vesicles / ultrastructure


  • Nerve Tissue Proteins
  • Neuropeptides
  • Phosphoproteins
  • Synapsins