We review the literature on school programs of prevention of consumption of tobacco and other addictive substances among adolescents. We describe the keys of these programs. The programs enforcing the abilities to resist the social pressure to the consumption of addictive substances report better results and they achieve significant reduction in the initiation of tobacco consumption. They also report promising results for alcohol and other addictive substances, but they are not so clearly supported. Average duration of the programs is between 8 and 12 ours a year, generally in 6th and 8th course. Other purposes of similar duration based on: self-esteem, the development of activities other than drug consumption, or the simple information on drugs, have not shown significant positive results for these ages.